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\u7279\u53d1\u6027\u81ea\u4e3b\u795e\u7ecf\u529f\u80fd\u4e0d\u5168\u53c8\u79f0\u4e3aShy-Drager\u7efc\u5408\u5f81\uff0c\u4ea6\u79f0\u539f\u53d1\u6027\u76f4\u7acb\u6027\u4f4e\u8840\u538b\uff0c1960\u5e74\u7531Shy\u53caDiager\u62a5\u544a\u800c\u5f97\u540d\u3002\u5176\u75c5\u56e0\u4e0d\u660e\uff0c\u8868\u73b0\u4e3a\u81ea\u4e3b\u795e\u7ecf\u529f\u80fd\u7d0a\u4e71\u3002\u4e34\u5e8a\u5f88\u5c11\u89c1\uff0c\u591a\u53d1\u751f\u4e8e\u4e2d\u8001\u5e74\uff0c\u7537\u5973\u53d1\u75c5\u7387\u65e0\u660e\u663e\u5dee\u5f02\u3002\u5e38\u56e0\u4f4e\u8840\u538b\u3001\u6ccc\u5c3f\u7cfb\u75c7\u72b6\u53ca\u6027\u529f\u80fd\u4f4e\u4e0b\u5c31\u533b\u3002(\u4e00\uff09\u75c5\u7406\u751f\u7406Oppenheimer(1972)\u5c06<\/p>\n
\u83b7\u5f97\u6027\u514d\u75ab\u7f3a\u9677\u7efc\u5408\u5f81\u7684\u75c5\u7406\u539f\u56e0<\/p>\n
HIV\u662f\u4e00\u79cd\u9006\u8f6c\u5f55\u75c5\u6bd2\uff0c\u5176\u9006\u8f6c\u5f55\u8fc7\u7a0b\u5c31\u662f\u5728\u75c5\u6bd2\u9006\u8f6c\u5f55\u9176\u7684\u4f5c\u7528\u4e0b\uff0c\u4ee5\u75c5\u6bd2RNA\u4e3a\u6a21\u677f\u5408\u6210\u524d\u75c5\u6bd2DNA\u7684\u8fc7\u7a0b\u3002\u75c5\u6bd2\u9006\u8f6c\u5f55\u9176\u5728\u75c5\u6bd2\u751f\u547d\u5468\u671f\u4e2d\u7684\u72ec\u7279\u529f\u80fd\u4f7f\u5176\u6210\u4e3a\u6297\u75c5\u6bd2\u6cbb\u7597\u7684\u91cd\u8981\u9776\u70b9 \u3002\u9006\u8f6c\u5f55\u9176\u6291\u5236\u5242\u80fd\u591f\u7279\u5f02\u6027\u4f5c\u7528\u4e8e\u75c5\u6bd2\u9006\u8f6c\u5f55\u9176\uff0c\u6291\u5236\u5176\u6d3b\u6027\uff0c\u4ece\u800c\u6cbb\u7597\u827e\u6ecb\u75c5\u3002<\/p>\n
\u9ad8\u8840\u7cd6\u75c7\u7684\u5206\u7c7b\u4f9d\u636e\u548c\u75c5\u56e0<\/p>\n
\uff081\uff09\u751f\u7406\u6027\u9ad8\u8840\u7cd6\uff1a \u5728\u9ad8\u7cd6\u996e\u98df\u540e1-2h\uff0c\u8fd0\u52a8\u3001\u60c5\u7eea\u7d27\u5f20\u3001\u996e\u9152\u7b49\u5f15\u8d77\u4ea4\u611f\u795e\u7ecf\u5174\u594b\u548c\u5e94\u6fc0\u60c5\u51b5\u4e0b\u53ef\u81f4\u8840\u7cd6\u77ed\u671f\u5347\u9ad8\u3002\uff082\uff09\u75c5\u7406\u6027\u9ad8\u8840\u7cd6\uff1a \u2460\u5404\u578b\u7cd6\u5c3f\u75c5\u53ca\u7532\u72b6\u817a\u529f\u80fd\u4ea2\u8fdb\u3001Cushing\u75c5\u3001\u80a2\u7aef\u80a5\u5927\u75c7\u3001\u533b|\u5b66\u6559\u80b2\u7f51\u641c\u96c6\u6574\u7406\u55dc\u7edc\u7ec6\u80de\u7624\u7b49\u5185\u5206\u6ccc\u75be\u75c5\uff1b\u2461\u9885\u5916\u4f24\u9885\u5185\u51fa\u8840\uff0c\u8111\u819c\u708e\u7b49\u5f15\u8d77\u9885\u5185\u538b\u5347\u9ad8\u523a\u6fc0\u8840\u7cd6\u4e2d\u67a2\u4ee5\u53ca\u5728\u75be\u75c5<\/p>\n
\u6ccc\u4e73\u7d20(prl)\u5174\u594b\u8bd5\u9a8c\u7684\u6b63\u5e38\u503c\u53ca\u4e34\u5e8a\u610f\u4e49<\/p>\n
\u6b63\u5e38\u503c\u3000\u3000\u6b63\u5e38\u4eba\u7ed9\u836f90\u5206\u949f\u540e\u51fa\u73b0\u5cf0\u503c\uff0c\u8f83\u57fa\u7840\u503c\u589e\u52a03\u500d\u4ee5\u4e0a\u6216\u5cf0\/\u57fa\u6bd4\u503c>2.5\uff0c\u529f\u80fd\u6027\u9ad8\u50ac\u4e73\u7d20\u8840\u75c7\u60a3\u8005\u53cd\u5e94\u4e0e\u6b63\u5e38\u4eba\u76f8\u4f3c\u3002\u3000\u3000\u4e34\u5e8a\u610f\u4e49\u3000\u3000PRL\u7624\u60a3\u8005\u65e0\u53cd\u5e94\u6216\u53cd\u5e94\u5ef6\u8fdf\uff0c\u57fa\u5cf0\/\u57fa\u6bd4\u503c<\/p>\n
\u6ccc\u4e73\u7d20(prl)\u5174\u594b\u8bd5\u9a8c\u7684\u4e34\u5e8a\u610f\u4e49\u53ca\u6ce8\u610f\u4e8b\u9879<\/p>\n
\u4e34\u5e8a\u610f\u4e49\u3000\u3000PRL\u7624\u60a3\u8005\u65e0\u53cd\u5e94\u6216\u53cd\u5e94\u5ef6\u8fdf\uff0c\u57fa\u5cf0\/\u57fa\u6bd4\u503c<\/p>\n
\u6ccc\u4e73\u7d20(prl)\u5174\u594b\u8bd5\u9a8c\u7684\u6ce8\u610f\u4e8b\u9879\u53ca\u68c0\u67e5\u8fc7\u7a0b<\/p>\n
\u6ce8\u610f\u4e8b\u9879\u3000\u3000\u68c0\u67e5\u524d\u7981\u5fcc\uff1a\u6ce8\u610f\u6b63\u5e38\u7684\u996e\u98df\uff0c\u6ce8\u610f\u6b63\u5e38\u7684\u4f5c\u606f\uff0c\u9632\u6b62\u5185\u5206\u6ccc\u6df7\u4e71\u3002\u7981\u7528\u5f71\u54cd\u50ac\u4e73\u7d20\u5206\u6ccc\u7684\u836f\u7269\u3002\u3000\u3000\u68c0\u67e5\u65f6\u8981\u6c42\uff1a\u79ef\u6781\u914d\u5408\u533b\u751f\u7684\u8981\u6c42\u3002\u6ce8\u610f\u6e05\u6668\u7a7a\u8179\u57fa\u7840\u72b6\u6001\u4e0b\u8fdb\u884c\uff0c\u5148\u62bd\u8840\u6d4bPRL\u57fa\u7840\u503c\u3002\u6ce8\u610f\u8bd5\u9a8c\u8981\u4e25\u683c\u6309\u7167\u89c4\u5b9a\u65f6\u95f4\u95f4\u9694\u8fdb\u884c\u62bd\u8840\u68c0\u67e5\u3002\u3000\u3000\u68c0\u67e5\u8fc7\u7a0b\u3000\u3000\u65b9\u6cd5\uff1a\u3000\u3000\u2460\u6e05\u6668\u7a7a\u8179\u57fa\u7840\u72b6\u6001\u4e0b\u8fdb\u884c\uff0c\u5148\u62bd\u8840\u6d4bPRL\u57fa<\/p>\n
\u6563\u53d1\u6027\u8111\u708e\u7684\u75c5\u7406\u53ca\u75c5\u56e0<\/p>\n
\u75c5\u7406\u3000\u3000\u4e00\u3001\u75c5\u6bd2\u6027\u8111\u708e\u6539\u53d8\u3000\u3000\u8089\u773c\u53ef\u89c1\u8111\u819c\u8840\u7ba1\u660e\u663e\u6269\u5f20\u5145\u8840\uff0c\u86db\u7f51\u819c\u4e0b\u8154\u8111\u810a\u6db2\u8f7b\u5fae\u6df7\u6d4a\u6216\u5448\u6de1\u9ec4\u8272\uff0c\u4e2a\u522b\u751a\u81f3\u5448\u80f6\u51bb\u6837\uff0c\u8111\u7ec4\u7ec7\u660e\u663e\u80bf\u80c0\uff0c\u8111\u56de\u589e\u5bbd\u3001\u8111\u6c9f\u53d8\u7a84\u3002\u8111\u76ae\u8d28\u6539\u53d8\u8f83\u8457\uff1b\u8f6f\u5316\u3001\u574f\u6b7b\u3001\u6216\u5f62\u6210\u542b\u574f\u6b7b\u7ec4\u7ec7\u53ca\u6de1\u9ec4\u8272\u6db2\u4f53\u7684\u6db2\u5316\u8154\u3002\u8f6f\u5316\u574f\u6b7b\u533a\u8840\u7ba1\u51cf\u5c11\uff0c\u6613\u88ab\u5438\u9664\u3002\u8111\u7684\u5207\u9762\u89c1\u767d\u5357\u533a\u5448\u7c89\u7ea2\u8272\uff0c\u8111\u5ba4\u53d8\u7a84\u3002\u8111\u5e72\u4f53\u79ef\u53ef\u589e\u5927<\/p>\n
\u5c0f\u5b69\u5148\u5fc3\u75c5\u7684\u4f53\u5f81\u53ca\u75c5\u7406<\/p>\n
\u4f53\u5f81\uff1a\u5fc3\u5c16\u640f\u52a8\u589e\u5f3a\u5e76\u5411\u5de6\u4e0b\u79fb\u4f4d\uff0c\u5fc3\u6d4a\u97f3\u754c\u5411\u5de6\u4e0b\u6269\u5927\u3002\u80f8\u9aa8\u5de6\u7f18\u7b2c\u2161\u808b\u3000\u3000\u95f4\u504f\u5916\u4fa7\u6709\u54cd\u4eae\u7684\u8fde\u7eed\u6027\u6742\u97f3\u3002\u5411\u5de6\u4e0a\u9888\u80cc\u90e8\u4f20\u5bfc\u3002\u4f34\u6709\u6536\u7f29\u671f\u6216\u8fde\u7eed\u6027\u7ec6\u9707\u98a4\u3002\u51fa\u73b0\u80ba\u52a8\u8109\u9ad8\u538b\u540e\uff0c\u53ef\u80fd\u4ec5\u542c\u5230\u6536\u7f29\u671f\u6742\u97f3\u3002\u80ba\u52a8\u8109\u7b2c\u4e8c\u97f3\u4ea2\u8fdb\u53ca\u5206\u88c2\uff0c\u80ba\u52a8\u8109\u74e3\u53ef\u6709\u76f8\u5bf9\u6027\u5173\u95ed\u4e0d\u5168\u7684\u8212\u5f20\u671f\u6742\u97f3\u3002\u5206\u6d41\u91cf\u8f83\u5927\u65f6\uff0c\u7531\u4e8e\u901a\u8fc7\u4e8c\u5c16\u74e3\u53e3\u8840\u6d41\u589e\u591a\u3002\u589e\u901f\uff0c\u5fc3\u5c16<\/p>\n
\u6563\u53d1\u6027\u8111\u708e\u7684\u75c5\u7406\u53ca\u75c5\u56e0<\/p>\n
\u75c5\u7406\u3000\u3000\u4e00\u3001\u75c5\u6bd2\u6027\u8111\u708e\u6539\u53d8\u3000\u3000\u8089\u773c\u53ef\u89c1\u8111\u819c\u8840\u7ba1\u660e\u663e\u6269\u5f20\u5145\u8840\uff0c\u86db\u7f51\u819c\u4e0b\u8154\u8111\u810a\u6db2\u8f7b\u5fae\u6df7\u6d4a\u6216\u5448\u6de1\u9ec4\u8272\uff0c\u4e2a\u522b\u751a\u81f3\u5448\u80f6\u51bb\u6837\uff0c\u8111\u7ec4\u7ec7\u660e\u663e\u80bf\u80c0\uff0c\u8111\u56de\u589e\u5bbd\u3001\u8111\u6c9f\u53d8\u7a84\u3002\u8111\u76ae\u8d28\u6539\u53d8\u8f83\u8457\uff1b\u8f6f\u5316\u3001\u574f\u6b7b\u3001\u6216\u5f62\u6210\u542b\u574f\u6b7b\u7ec4\u7ec7\u53ca\u6de1\u9ec4\u8272\u6db2\u4f53\u7684\u6db2\u5316\u8154\u3002\u8f6f\u5316\u574f\u6b7b\u533a\u8840\u7ba1\u51cf\u5c11\uff0c\u6613\u88ab\u5438\u9664\u3002\u8111\u7684\u5207\u9762\u89c1\u767d\u5357\u533a\u5448\u7c89\u7ea2\u8272\uff0c\u8111\u5ba4\u53d8\u7a84\u3002\u8111\u5e72\u4f53\u79ef\u53ef\u589e\u5927<\/p>\n
\u771f\u83cc\u6027\u80a0\u708e\u7684\u75c5\u7406\u53ca\u751f\u7406<\/p>\n
\u75c5\u7406\u3000\u3000\u5f15\u8d77\u771f\u83cc\u6027\u80a0\u708e\u7684\u75c5\u539f\u4e3b\u8981\u662f\u5ff5\u73e0\u83cc\uff0c\u5176\u6b21\u662f\u66f2\u83cc\u3001\u6bdb\u9709\u83cc\u3001\u7ec4\u7ec7\u80de\u6d46\u83cc\u3001\u526f\u7403\u5b62\u5b50\u83cc\u548c\u5730\u4e1d\u83cc\u7b49\u3002\u5076\u89c1\u7403\u5b62\u5b50\u83cc\u3001\u9a6c\u5c14\u5c3c\u83f2\u9752\u771f\u83cc\u548c\u65b0\u578b\u9690\u7403\u83cc\u3002\u5ff5\u73e0\u83cc\u5e7f\u6cdb\u5b58\u5728\u4e8e\u81ea\u7136\u754c\uff0c\u4e5f\u662f\u4eba\u4f53\u6b63\u5e38\u83cc\u7fa4\u4e4b\u4e00\uff0c\u4e3a\u6761\u4ef6\u81f4\u75c5\u6027\u771f\u83cc\u4e2d\u7684\u4e3b\u8981\u4e00\u5c5e\uff0c\u5171\u6709150\u4f59\u79cd\u3002\u5176\u4e2d\u4ee5\u767d\u5ff5\u73e0\u83cc\u548c\u70ed\u5e26\u5ff5\u73e0\u83cc\u6700\u5e38\u89c1\uff0c\u4e14\u81f4\u75c5\u6027\u8f83\u5f3a\u3002\u5ff5\u73e0\u83cc\u4e3a\u53cc\u76f8\u578b\u771f\u83cc<\/p>\n
\u7751\u7f18\u708e\u7684\u75c5\u56e0\u53ca\u75c5\u7406<\/p>\n
\u75c5\u56e0\u3000\u3000\u7531\u4e8e\u7751\u76ae\u8102\u817a\u53ca\u7751\u677f\u817a\u5206\u6ccc\u65fa\u76db\u76ae\u8102\u6ea2\u51fa\u591a\u5408\u5e76\u8f7b\u5ea6\u611f\u67d3\u6240\u81f4\u5176\u4e2d\u9cde\u5c51\u6027\u7751\u7f18\u708e\u591a\u4e3a\u9175\u6bcd\u6837\u9709\u83cc\u6216\u7ce0\u75b9\u7663\u83cc\uff1b\u6e83\u75a1\u6027\u7751\u7f18\u708e\u4ee5\u8461\u8404\u7403\u83cc\u4e3a\u4e3b\uff1b\u7726\u6027\u7751\u7f18\u708e\u5219\u662f\u6469\u4e00\u963f\u9644\u53cc\u6746\u83cc\uff08Mo-rax-Axenfeld\uff09\u611f\u67d3\u5f15\u8d77\u5176\u5b83\u5982\u98ce\u6c99\u70df\u5c18\u70ed\u548c\u5316\u5b66\u56e0\u7d20\u7b49\u523a\u6fc0\u5c48\u5149\u4e0d\u6b63\u773c\u75b2\u52b3\u7761\u7720\u4e0d\u8db3\u5168\u8eab\u62b5\u6297\u529b\u964d\u4f4e\u8425\u517b\u4e0d\u826f\u5982\u7ef4\u751f\u7d20B2\u7684\u7f3a\u4e4f<\/p>\n
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